Norocarp 50 mg for dogs 20 flavoured tablets
For analgesia and reduction of chronic inflammation in dogs
Norocarp 50mg Flavoured Tablets for Dogs
2. Qualitative and quantitative composition of Norocarp 50mg
Each tablet contains:
For a full list of excipients see section 6.1
3. Pharmaceutical form of Norocarp 50mg
Light brown, round, flat, bevel edged tablet
The tablets can be divided into equal halves.
4. Clinical Particulars of Norocarp 50mg
4.1 Target species:
4.2 Indications for use, specifying the target species:
For analgesia and reduction of chronic inflammation, for example in degenerative joint disease in the dog.
The tablets also can be used in the management of post operative pain.
Do not exceed the stated dose.
Do not use in cats. The elimination time of NSAIDs, including carprofen, in the cat is longer than in the dog and the therapeutic index is narrower. In the absence of specific data use in the cat is contra- indicated.
Do not use in dogs suffering from cardiac, hepatic or renal disease, where there is a possibility of gastrointestinal ulceration or bleeding, or where there is evidence of blood dyscrasia or hypersensitivity to the product. As with other NSAIDs there is a risk of rare idiosyncratic renal or hepatic adverse effects.
Do not use in puppies less than 4 months.
Do not use in case of hypersensitivity to active substance or to any of the excipients.
Refer to section 4.7 and 4.8
4.4 Special Warnings for each target species:
See sections 4.3 and 4.5.
4.5. Special precautions for use
Special precautions for use in animals:
Use in aged dogs may involve additional risk. If such a use cannot be avoided, such dogs may require a reduced dosage and careful clinical management.
Avoid use in any dehydrated, hypovolaemic or hypotensive dog, as there is a potential rise of increased renal toxicity.
NSAIDs can cause inhibition of phagocytosis and hence in the treatment of inflammatory conditions associated with bacterial infection, appropriate concurrent antimicrobial therapy should be instigated.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals:
In case of accidental ingestion seek medical advice and show the package leaflet or the label to the physician. Wash hands after handling product.
4.6 Adverse reactions (frequency and seriousness):
Typical undesirable effects associated with NSAIDs, such as vomiting, soft faeces/diarrhoea, faecal occult blood, loss of appetite and lethargy have been reported. These adverse reactions generally occur within the first treatment week and are in most cases transient and disappear following termination of the treatment but in very rare cases may be serious or fatal.
As with other NSAIDs there is a risk of rare renal or idosyncratic hepatic adverse events.
4.7 Use during pregnancy, lactation or lay:
Studies in laboratory species (rat and rabbit) have shown evidence of foetotoxic effects of carprofen at doses close to the therapeutic dose. The safety of the veterinary medicinal product has not been established during pregnancy and lactation. Do not use in pregnant or lactating bitches. For breeding animals, do not use during reproduction period.
4.8. Interaction with other medicinal products and other forms of interaction:
Carprofen is highly bound to plasma proteins and compete with other highly bound drugs, which can increase their respective toxic effects. Do not use this veterinary medicinal product concurrently with or within 24 hours of other NSAIDs or concurrently with glucocorticoids.
Concurrent administration of potentially nephrotoxic drugs should be avoided. Refer also to section 4.5.
Do not administer concurrently with anticoagulants.
4.9. Amounts to be administered and administration route:
For oral administration. The tablets are palatable and willingly consumed by most dogs when offered.
2 to 4 mg carprofen per kg bodyweight per day.
An initial dose of 4 mg carprofen per kg bodyweight per day given as a single daily dose or in two equally divided doses may, subject to clinical response, be reduced after 7 days to 2 mg carprofen/kg bodyweight/day given as a single dose.
Duration of treatment will be dependent upon the response seen. Long term treatment should be under regular veterinary supervision.
To extend analgesic and anti-inflammatory cover post-operatively, parenteral preoperative treatment may be followed with Carprofen tablets at 4mg/kg/day for up to 5 days.
Do not exceed the stated dose.
4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary:
There is no specific antidote for carprofen over dosage but general supportive therapy as applied to clinical over dosage with NSAIDs should be applied.
4.11 Withdrawal period:
5. pharmacological properties of Norocarp 50mg
ATC Vet Code: QM01AE91 Anti-inflammatory
5.1 Pharmacodynamic properties:
Carprofen is a member of the 2 –arylpropionic acid group of non steroidal anti-inflammatory drugs (NSAIDs) and possesses anti-inflammatory, analgesic and antipyretic activity.
Carprofen like most other NSAIDs is an inhibitor of the enzyme cyclo-oxygenase of the arachidonic acid cascade. However the inhibition of prostaglandin synthesis by carprofen is slight in relation to its anti-inflammatory and analgesic potency. At therapeutic doses in the dog inhibition of the products of cyclo-oxygenase (prostaglandins and thromboxanes) or lipoxygenase (leukotrienes) has been absent or slight. The precise mode of action of carprofen is not clear.
5.2 Pharmacokinetic Particulars
After a single oral administration of 4 mg of carprofen per kg of bodyweight in dogs, the time to obtain a maximum plasmatic concentration of 31 μg/ml is 2.5 hours. The oral bioavailability is more than 90% of the total dose. Carprofen is more than 98% bound to plasma proteins and its volume of distribution is low. Carprofen is excreted in the bile with 70% of an intra-venous dose of carprofen being eliminated in the faeces, mainly as the glucuronide conjugate. Carprofen undergoes an enantioselective enterohepatic cycle in dogs, with only the S(+) enantiomer being significantly recycled. The plasmatic clearance of the S(+) carprofen is about twice that of the R(-) carprofen. The biliary clearance of S(+) carprofen seems to be subject to stereoselectively too as it is about three times higher than that of R(-) carprofen.
Carprofen is mainly excreted in the bile with 70% of an intra-venous dose of carprofen being eliminated in the faeces, mainly as the glucuronide conjugate, and 8-15% via urine.
6. Pharmaceutical particulars of Norocarp 50mg
6.1 List of excipients:
Sodium lauryl sulphate
Spray dried Pig liver powder EHT
Yeast extract (dried)
6.3 Shelf life:
Shelf life of the veterinary medicinal product as packaged for sale: 18 months.
Shelf-life after first opening the immediate packaging: 24 hours.
Any divided tablet portions remaining after 24 hours should be discarded.
6.4 Special precautions for storage:
Store in a dry place.
Protect from light.
Do not store above 25ºC
Divided tablets should be stored in the blister pack.
Due to the palatable nature of the tablets, store in a secure location. Severe adverse reactions may occur if large quantities are ingested. If you suspect your dog has consumed Carprofen Flavoured/Chewable Tablets above the labelled dose, please contact your veterinarian.