Rycarfa 20 mg for dogs 100 tablets

Reduction of inflammation and pain caused by musculoskeletal disorders and degenerative joint disease in dogs

Prescription required* (Exceptions apply)

Rycarfa 20 mg tablets for dogs


Each tablet contains:

Active substance:
Carprofen 20.00 mg

Ferric oxide red (E172) 0.61 mg
Ferric oxide black (E172) 0.38 mg

For a full list of excipients, see section 6.1.


Round, dark brown, marbled tablets with visible darker spots, one-side scored and bevel-edged.
The tablet can be divided into equal halves.


4.1 Target species


4.2 Indications for use, specifying the target species

Reduction of inflammation and pain caused by musculoskeletal disorders and degenerative joint disease. As a follow up to parenteral analgesia in the management of post operative pain.

4.3 Contraindications

Do not use in cats.
Do not use in pregnant or lactating bitches.
Do not use in dogs less than 4 months of age.
Do not use in case of hypersensitivity to active substance or to any of the excipients.
Do not use in dogs suffering from cardiac, hepatic or renal disease, where there is a possibility of gastrointestinal ulceration or bleeding, or where there is evidence of a blood dyscrasia.

4.4 Special warnings for each target species

Refer to Sections 4.3 and 4.5.

4.5 Special precautions for use

Special precautions for use in animals

Use in aged dogs may involve additional risk.
If such a use cannot be avoided, dogs may require careful clinical management.
Avoid use in any dehydrated, hypovolaemic or hypotensive dog, as there is a potential risk of increased renal toxicity.
NSAIDs can cause inhibition of phagocytosis and hence in the treatment of inflammatory conditions associated with bacterial infection, appropriate concurrent antimicrobial therapy should be instigated.

See section 4.8.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

In the event of accidental ingestion of the tablets, seek medical advice and show the doctor the package leaflet. Wash hands after handling the product.

4.6 Adverse reactions (frequency and seriousness)

Typical undesirable effects associated with NSAIDs such as vomiting, soft faeces/diarrhoea, faecal occult blood, loss of appetite and lethargy have been reported. These adverse reactions occur generally within the first treatment week and are in most cases transient and disappear following termination of the treatment but in very rare cases may be serious or fatal.

If adverse reactions occur, use of the product should be stopped and the advice of a veterinarian should be sought.

As with other NSAIDs there is a risk of rare renal or idiosyncratic hepatic adverse events.

4.7 Use during pregnancy, lactation or lay

Studies in laboratory species (rat and rabbit) have shown evidence of foetotoxic effects of carprofen at doses close to the therapeutic dose. The safety of the veterinary medicinal product has not been established during pregnancy and lactation. Do not use in pregnant or lactating bitches.

4.8 Interaction with other medicinal products and other forms of interaction

Do not administer other NSAIDs and glucocorticoids concurrently or within 24 hours of administration of the product. Carprofen is highly bound to plasma proteins and may compete with other highly bound drugs, which can lead to toxic effects.

Concurrent administration of potential nephrotoxic drugs should be avoided.

4.9 Amounts to be administered and administration route

For oral administration.
2 to 4 mg carprofen per kg bodyweight per day.
An initial dose of 4 mg carprofen per kg bodyweight per day given as a single daily dose or in two equally divided doses may, subject to clinical response, be reduced after 7 days to 2 mg carprofen/kg bodyweight/day given as a single dose.
Duration of treatment will be dependent upon the response seen. Long term treatment should be under regular veterinary supervision.
To extend analgesic and anti-inflammatory cover post-operatively, parenteral preoperative treatment may be followed with Carprofen tablets at 4 mg/kg/day for up to 5 days.

4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary

Although studies investigating the safety of carprofen at overdose have been performed, no signs of toxicity appeared when dogs were treated with carprofen at levels up to 6 mg/kg twice daily for 7 days (3 times the recommended dose rate of 4mg/kg) and 6mg/kg once daily for a further 7 days. (1.5 times the recommended dose rate of 4 mg/kg).

There is no specific antidote for carprofen overdosage but general supportive therapy, as applied to clinical overdosage with NSAIDs should be applied.

4.11 Withdrawal period(s)

Not applicable.


Pharmacotherapeutic group: Antiinflammatory and antirheumatic products, non-steroids
ATCvet code: QM01AE91

5.1 Pharmacodynamic properties

Carprofen possesses anti-inflammatory, analgesic and antipyretic activity. Like most other NSAID’s, carprofen is an inhibitor of the enzyme cyclo-oxygenase of the arachidonic acid cascade.
However, the inhibition of prostaglandin synthesis by carprofen is slight in relation to its anti-inflammatory and analgesic potency. The precise mode of action of carprofen is not clear.

Carprofen is a chiral drug with the S(+) enantiomer being more active than the R(-) enantiomer. There is no chiral inversion between the enantiomers in-vivo.

5.2 Pharmacokinetic particulars

Carprofen is well absorbed after oral administration (>90%) and is highly protein bound. Peak plasma concentrations are achieved between 1 h and 3 h after administration.
Carprofen is characterized by a half-life of approximately 10 hours in dogs.
Carprofen is eliminated in dogs primarily by means of biotransformation in the liver, followed by rapid excretion of the resulting metabolites in feces (70-80%) and urine (10-20%). Some enterohepatic circulation has been detected.


6.1 List of excipients

Lactose monohydrate
Maize starch
Ferric oxide red (E172)
Ferric oxide black (E172)
Povidone K30
Sodium starch glycolate, type A
Colloidal anhydrous silica
Meat flavour 10022
Magnesium stearate

6.2 Incompatibilities

Not applicable.

6.3 Shelf life

Shelf-life of the veterinary medicinal product as packaged for sale: 3 years.
Return any halved tablet to the opened blister and use within 24 hours.

6.4. Special precautions for storage

Store in the original package in order to protect from light and moisture.

Order within 21h 3m 52s (before 12AM)
And receive your order
on Tuesday 11 August