Rimadyl 20 mg for dogs 100 chewable tablets

For analgesia and reduction of chronic inflammation in dogs

Prescription required* (Exceptions apply)

Rimadyl Palatable Tablets for dogs 20 mg


Each tablet contains 20 mg Carprofen.

For the full list of all other excipients see section 6.1


A light brown square tablet with “R” engraved on one side and bisected on the other side.


4.1 Target species


4.2 Indications for use, specifying the target species

For analgesia and reduction of chronic inflammation, for example in degenerative joint disease in the dog.
The tablets can also be used in the management of post-operative pain.

4.3 Contraindications

Do not exceed the stated dose.
The elimination time of NSAIDs, including carprofen, in the cat is longer than in the dog and the therapeutic index is narrower. In the absence of specific data use in the cat is contra-indicated.
Do not use in dogs suffering from cardiac, hepatic or renal disease, where there is a possibility of gastro-intestinal ulceration or bleeding, or where there is evidence of blood dyscrasia or hypersensitivity to the product. As with other NSAIDs there is a risk of rare idiosyncratic renal or hepatic adverse events.
Do not administer other NSAIDs concurrently or within 24 hours of each other. Some NSAIDs may be highly bound to plasma proteins and compete with other highly bound drugs, which can lead to toxic effects.

4.4. Special warnings for each target species


4.5 Special precautions for use

i) Special precautions for use in animals

Use in dogs less than 6 weeks of age, or in aged dogs, may involve additional risk. If such a use cannot be avoided, such dogs may require a reduced dosage and careful clinical management.
Avoid use in any dehydrated, hypovolaemic or hypotensive dog, as there is a potential rise of increased renal toxicity.
Concurrent administration of potential nephrotoxic drugs should be avoided.
NSAID’s can cause inhibition of phagocytosis and hence in the treatment of inflammatory conditions associated with bacterial infection, appropriate concurrent antimicrobial therapy should be instigated.

ii) Special precautions to be taken by the person administering the veterinary medicinal product to animals

In the event of accidental ingestion of the tablets, seek medical advice and show the doctor what has been taken. Wash hands after handling the product.

4.6 Adverse reactions (frequency and seriousness)

Experimental and clinical evidence suggests that for carprofen in the dog gastro-intestinal tract ulceration is rare, and only occurs at dosages well above the therapeutic dose.

4.7. Use during pregnancy, lactation or lay

In the absence of any specific studies in pregnant bitches, such use is not indicated.

4.8 Interaction with other medicinal products and other forms of interaction

No significant drug interactions have been reported for carprofen. The acute toxicity of carprofen in animals was not significantly affected in tests with fifteen commonly used (or commonly available) drugs. These were acetylsalicylic acid, amphetamine, atropine, chlorpromazine, diazepam, diphenhydramine, ethyl alcohol, hydrochlorothiazide, imipramine, meperidine, propoxyphene, pentobarbital, sulfisoxazole, tetracycline and tolbutamide. (Jeunet, 1982).

Whilst carprofen and warfarin may both be bound to plasma proteins, they may be used concurrently provided the clinical situation is carefully monitored since it has been shown that they bind to two distinct sites on human and bovine serum albumin [Sudlow et al (1976), Crouthamel and Popick (1979) and Jeunet (1982)].

4.9 Amounts to be administered and administration route

For oral administration. The tablets are palatable and willingly consumed by most dogs when offered.
An initial dose of 2 to 4 mg carprofen per kg bodyweight per day is recommended to be given as a single dose or in two equally divided doses.
Subject to clinical response, the dose may be reduced after 7 days to 2 mg carprofen/kg bodyweight/day given as a single dose.
To extend analgesic and anti-inflammatory cover post-operatively, parenteral therapy with Rimadyl Small Animal Injection may be followed with the tablets at 4mg/kg/day for up to 5 days.
Duration of treatment will be dependent upon the response seen. Long term treatment should be under regular veterinary supervision.

4.10. Overdose (symptoms, emergency procedures, antidotes), if necessary

There is no specific antidote for carprofen overdosage but general supportive therapy, as applied to clinical overdosage with NSAID’s, should be applied.

4.11. Withdrawal period

Not applicable.


ATC Vet code: QM01AE91 Anti-inflammatory

Mechanism of Action
Carprofen is a member of the 2-arylpropionic acid group of non-steroidal anti-inflammatory drugs (NSAIDs), and possesses anti-inflammatory, analgesic and antipyretic activity.
Carprofen, like most other NSAIDs is an inhibitor of the enzyme cyclo-oxygenase of the arachidonic acid cascade. However, the inhibition of prostaglandin synthesis by carprofen is slight in relation to its anti-inflammatory and analgesic potency. At therapeutic doses in the dog inhibition of the products of cyclo-oxygenase (prostaglandins and thromboxanes) or lipoxygenase (leucotrienes) has been absent or slight. Since prostaglandin inhibition is thought to underlie the principal toxic side effects of NSAIDs, lack of cyclo-oxygenase inhibition may explain the excellent gastro-intestinal and renal tolerance of carprofen seen in this species. The precise mode of action of carprofen is not clear.
Following repeated therapeutic dosing for 8 weeks, carprofen has been shown to have no detrimental effect on chronically arthritic canine cartilage in a model of canine osteoarthritis.
In addition, therapeutic concentrations of carprofen have been demonstrated (in vitro) to increase proteoglycan synthesis in chondrocytes from canine arthritic cartilage.
Stimulation of proteoglycan synthesis will narrow the difference between the rate of degeneration and regeneration of cartilage matrix resulting in a slowing of the progression of cartilage loss.


6.1 List of excipients

Pig Liver Powder
Vegetable Protein Hydrolyzed
Maize Starch
Lactose Monohydrate
Confectioner’s Sugar
Wheat Germ
Calcium Hydrogen Phosphate Anhydrous
Corn Syrup 81.5% solids
Magnesium Stearate
Water Purified*

* Not present in the finished product.

6.2 Incompatibilities

None known.

6.3 Shelf-life

Shelf-life of the veterinary medicinal product as packaged for sale: 3 years.

6.4. Special precautions for storage

Store in a dry place. Protect from light. Do not store above 25°C.
Due to the palatable nature of the tablets, store in a secure location. Severe adverse reaction may occur if large quantities are ingested. If you suspect your dog has consumed Rimadyl Palatable Tablets above the labelled dose, please contact your veterinarian.

Order within 0h 7m 28s (before 12AM)
And receive your order
on Monday 10 August