Zoetis
Advocin 2.5 % - solution for injection - cattle and pigs - 100 ml

Treatment of respiratory disease, mastitis and enteric infections in cattle and pigs

Prescription required* (Exceptions apply)

Advocin is a medium yellow to amber solution for injection for cattle and pigs.

Each Advocin ml contains:

  • Active substance:
Name Danofloxacin
Advocin 25 mg/ml solution for injection 25.00 mg (Equivalent to 31.73 mg Danofloxacin mesylate)
Advocin 100 mg/ml solution for injection for cattle 100.00 mg (Equivalent to 228.4mg Danofloxacin mesylate)
  • List of excipients:
    • Phenol
    • Monothioglycerol
    • Povidone K 15
    • 2-pyrrolidone
    • Magnesium oxide
    • Hydrochloric acid
    • Sodium hydroxide
    • Water for injection

Indications for use of Advocin, specifying the target species:

  • Cattle:
    • Treatment of bovine respiratory disease caused by Mannheimia haemolytica, Pasteurella multocida and Histophilus somni sensitive to danofloxacin.
    • For the treatment of acute bovine mastitis caused by Escherichia coli sensitive to danofloxacin.
  • Pigs
    • The treatment of respiratory disease caused by P.multocida and A.pleuropneumoniae, and the treatment of enteric infection caused by E.coli in pigs.
  • In neo-natal calves:
    • Treatment of enteric infections caused by Escherichia coli sensitive to danofloxacin.
  • Do not use in cases of hypersensitivity to the active substance, to other (fluoro)quinolones or to any of the excipients.

Withdrawal periods:

Advocin 25 mg/ml:

  • Cattle:

    • Meat: 5 days
    • Milk: 48 hours
  • Pigs:
    • Meat: 3 days

Advocin 100 mg/ml:

  • Cattle:

    • Meat and offal: 8 days
    • Milk: 4 days

Amounts of Advocin to be administered and administration route:

Advocin 25 mg/ml:

  • Cattle:

    • Administer by the intramuscular or intravenous routes at a dosage rate of 1.25 mg/kg body weight (1 ml/20 kg body weight). Three treatments should be given at 24 hour intervals. Treatment may be extended by up to 2 additional days for animals not fully recovered after the initial 3 treatments. For the treatment of cattle weighing more than 400 kg, the dose should be divided so that not more than 20 ml are injected at one site.
  • Pigs
    • Administer by intramuscular injection at a dosage rate of 1.25 mg/kg body weight (1 ml/20 kg body weight). Three treatments should be given at 24 hour intervals. For the treatment of pigs weighing more than 100 kg, the dose should be divided so that no more than 5 ml are injected at one site.
    • Seek veterinary advice regarding use of appropriately sized needles and syringes when dosing small animals.
    • An appropriately graduated syringe must be used to allow accurate administration of the required dose volume. This is particularly important when injecting small volumes, e.g. piglets less than 2 kg body weight. When dosing a large number of animals from a single bottle, the use of an aspirating needle is recommended to avoid excessive broaching of the stopper.

Advocin 100 mg/ml:

  • Cattle:

    • 6 mg/kg body weight (1 ml/30 kg body weight) as a single injection by the subcutaneous or intravenous route.
    • If clinical signs of respiratory or enteric disease persist 48 hours after the first injection, an additional dose at 6 mg/kg body weight may be administered.
    • It is recommended to treat animals in the early stages of disease and to evaluate the response to treatment within 48 hours.
    • For the treatment of acute bovine mastitis, the product should be administered at 6 mg/kg body weight (1 ml/30 kg body weight) as a single injection by the subcutaneous or intravenous route. The clinical signs should be monitored carefully and supportive therapy should be given as appropriate. If clinical signs of acute bovine mastitis persist 36-48 hours after the first injection, the antibiotic treatment strategy should be reviewed. It is recommended to treat animals in the early stages of disease and to evaluate the response to treatment within 36-48 hours.
    • For treatment of cattle weighing more than 450 kg, divide the subcutaneous dose so that no more than 15 ml are injected at one site.
    • When dosing a large number of animals from a single vial, the use of an automatic syringe is recommended to avoid excessive broaching of the rubber stopper.
    • To ensure a correct dosage body weight should be determined as accurately as possible to avoid underdosing.

Advocin is a medium yellow to amber solution for injection for cattle and pigs.

Each Advocin ml contains:

  • Active substance:
Name Danofloxacin
Advocin 25 mg/ml solution for injection 25.00 mg (Equivalent to 31.73 mg Danofloxacin mesylate)
Advocin 100 mg/ml solution for injection for cattle 100.00 mg (Equivalent to 228.4mg Danofloxacin mesylate)
  • List of excipients:
    • Phenol
    • Monothioglycerol
    • Povidone K 15
    • 2-pyrrolidone
    • Magnesium oxide
    • Hydrochloric acid
    • Sodium hydroxide
    • Water for injection

Indications for use of Advocin, specifying the target species:

  • Cattle:
    • Treatment of bovine respiratory disease caused by Mannheimia haemolytica, Pasteurella multocida and Histophilus somni sensitive to danofloxacin.
    • For the treatment of acute bovine mastitis caused by Escherichia coli sensitive to danofloxacin.
  • Pigs
    • The treatment of respiratory disease caused by P.multocida and A.pleuropneumoniae, and the treatment of enteric infection caused by E.coli in pigs.
  • In neo-natal calves:
    • Treatment of enteric infections caused by Escherichia coli sensitive to danofloxacin.
  • Do not use in cases of hypersensitivity to the active substance, to other (fluoro)quinolones or to any of the excipients.

Withdrawal periods:

Advocin 25 mg/ml:

  • Cattle:

    • Meat: 5 days
    • Milk: 48 hours
  • Pigs:
    • Meat: 3 days

Advocin 100 mg/ml:

  • Cattle:

    • Meat and offal: 8 days
    • Milk: 4 days

Amounts of Advocin to be administered and administration route:

Advocin 25 mg/ml:

  • Cattle:

    • Administer by the intramuscular or intravenous routes at a dosage rate of 1.25 mg/kg body weight (1 ml/20 kg body weight). Three treatments should be given at 24 hour intervals. Treatment may be extended by up to 2 additional days for animals not fully recovered after the initial 3 treatments. For the treatment of cattle weighing more than 400 kg, the dose should be divided so that not more than 20 ml are injected at one site.
  • Pigs
    • Administer by intramuscular injection at a dosage rate of 1.25 mg/kg body weight (1 ml/20 kg body weight). Three treatments should be given at 24 hour intervals. For the treatment of pigs weighing more than 100 kg, the dose should be divided so that no more than 5 ml are injected at one site.
    • Seek veterinary advice regarding use of appropriately sized needles and syringes when dosing small animals.
    • An appropriately graduated syringe must be used to allow accurate administration of the required dose volume. This is particularly important when injecting small volumes, e.g. piglets less than 2 kg body weight. When dosing a large number of animals from a single bottle, the use of an aspirating needle is recommended to avoid excessive broaching of the stopper.

Advocin 100 mg/ml:

  • Cattle:

    • 6 mg/kg body weight (1 ml/30 kg body weight) as a single injection by the subcutaneous or intravenous route.
    • If clinical signs of respiratory or enteric disease persist 48 hours after the first injection, an additional dose at 6 mg/kg body weight may be administered.
    • It is recommended to treat animals in the early stages of disease and to evaluate the response to treatment within 48 hours.
    • For the treatment of acute bovine mastitis, the product should be administered at 6 mg/kg body weight (1 ml/30 kg body weight) as a single injection by the subcutaneous or intravenous route. The clinical signs should be monitored carefully and supportive therapy should be given as appropriate. If clinical signs of acute bovine mastitis persist 36-48 hours after the first injection, the antibiotic treatment strategy should be reviewed. It is recommended to treat animals in the early stages of disease and to evaluate the response to treatment within 36-48 hours.
    • For treatment of cattle weighing more than 450 kg, divide the subcutaneous dose so that no more than 15 ml are injected at one site.
    • When dosing a large number of animals from a single vial, the use of an automatic syringe is recommended to avoid excessive broaching of the rubber stopper.
    • To ensure a correct dosage body weight should be determined as accurately as possible to avoid underdosing.
71.00
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And receive your order
on Thursday 21 November
AIR FREIGHT

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