Ivomec solution for injection for sheep 50 ml
For the treatment of infections and infestations due to internal and external parasites and parasitic infections due to internal parasites in sheep
FOR VETERINARY USE ONLYFor the treatment of infections and infestations due to internal and external parasites and parasitic infections due to internal parasites in sheep.
Discovered and developed by scientists from the Merck Research Laboratories, IVOMEC contains ivermectin, a unique chemical entity. Its convenience, broad-spectrum efficacy and wide safety margin make it an excellent antiparasitic product for sheep.One low-volume dose effectively controls internal and external parasites and internal parasites of sheep that can impair health and productivity.
IVOMEC Injection is a ready-to-use sterile solution containing the following ingredients per mL: 10 mg ivermectin, 0.40 mL glycerol formal and propylene glycol q.s. ad 1 mL.
IVOMEC Injection is formulated to deliver the recommended dose level of 200 µg ivermectin per kg of body weight in sheeps when given subcutaneously at the rate of 1 mL per 50 kg.Studies show that IVOMEC Injection is stable for five years when stored under normal conditions.
Ivermectin is the first in a series of antiparasitic agents derived from the avermectin family of compounds. The avermectins are highly active, broad-spectrum antiparasitic agents isolated from fermentation of the soil organism Streptomyces avermitilis.
IVOMEC Injection is indicated for the treatment of infections due to gastrointestinal roundworms, lungworms, and larval stages of the nasal bot in sheep:
Adults and immatures: Haemonchus contortus; Ostertagia circumcincta; Trichostrongylus colubriformis; Cooperia curticei; Oesophagostomum columbianum; Chabertia ovina
Adults: Trichostrongylus axei; Oesophagostomum venulosum; Trichuris ovis
Lungworms: Dictyocaulus filaria (adults and immatures)
Nasal bot: Oestrus ovis (all larval stages)
Dosage and administration:
The recommended dose level is 1 mL of IVOMEC Injection per 50 kg of body weight (200 µg of ivermectin per kg).
The recommended route of administration is by subcutaneous injection.
The solution may be given with any standard automatic or single-dose equipment.
Use sterile equipment.
The loose skin behind the shoulder is an acceptable site. In woolly sheep, be certain that the needle has penetrated the wool and skin before delivering the dose.
Mode of action:
Ivermectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated chloride channels, the macrocyclic lactones have a low affinity for other mammalian ligand-gated channels and they do not readily cross the blood-brain barrier.
1. Treated sheep must not be slaughtered for use in food for at least thirty-five (35) days after the latest treatment with this drug;
2. Not for use in ewes where milk is to be used for human consumption.
3. Keep this and all drugs out of the reach of children
1. Do not administer intravenously or intramuscularly.
2. Transitory discomfort has been observed in some animals following subcutaneous administration. A low incidence of soft tissue swelling at the injection site has been observed. These reactions have disappeared without treatment. Divide doses greater than 10 mL between injection sites to reduce occasional discomfort to site reaction. Different sites should be used for other parenteral products.
Following subcutaneous injections activity suggesting pain, sometimes intense but usually transient, has been seen in some sheep.Adequate vaccination against clostridial infections in sheep is recommended.Consult your veterinarian for advice on a vaccination program.
Store bottle in carton to protect from light.
IVOMEC Injection for Sheep is available in four ready to use sizes:50 mL, 200 mL, 500 mL and 1000 mL.
50 mL:Product 41330 CA, DIN 00630470, is supplied in a multiple-dose, rubber-capped bottle.
200 mL: Product 41331 CA, DIN 00630470, is contained in a soft, collapsible pack designed for use with automatic injection equipment.
500 mL: Product 41332 CA, DIN 00630470, is also contained in a collapsible pack designed for use with automatic injection equipment.
1000 mL: Product 41333 CA, DIN 00630470, is also contained in a collapsible pack designed for use with automatic injection equipment.