Merial
Eprinex multi pour-on for beef and dairy cattle 1 l

Indicated for treatment and control of parasites in beef and dairy cattle / Eprinomectin

Prescription required* (Exceptions apply)

Eprinex Pour-On for Beef and Dairy Cattle

Eprinex Qualitative and quantitative composition

Active substance: Eprinomectin 5 mg per ml

Eprinex Pharmaceutical form

Pour-on solution.

Eprinex Clinical particulars

Eprinex Target species

Beef and dairy cattle.

Eprinex Indications for use

Indicated for treatment and control of the following parasites:

Gastrointestinal Roundworms (Adult, L4 and Inhibited L4)

Ostertagia ostertagi

Cooperia spp.

Gastrointestinal Roundworms (Adult and L4)

Ostertagia spp.

Cooperia oncophora

Cooperia pectinata

Cooperia punctata

Cooperia surnabada

Haemonchus placei

Trichostongylus spp.

Trichostrongylus axei

Trichostrongylus colubriformis

Bunostomum phlebotomum

Nematodirus helvetianus

Oesophagostomum radiatum

Gastrointestinal roundworms (Adult)

Ostertagia lyrata

Oesophagostomum radiatum

Trichuris spp.

Lungworms (Adult and L4)

Dictyocaulus viviparus

Warbles (parasitic stages)

Hypoderma bovis

H.lineatum

Mange mites

Chorioptes bovis

Sarcoptes scabiei

Lice

Damalinia bovis (biting lice)

Linognathus vituli (sucking lice)

Haematopinus eurysternus (sucking lice)

Solenopotes capillatus (sucking lice)

While mite and louse numbers decline rapidly following treatment, due to the feeding habits of the parasites, in some cases several weeks may be required for complete eradication.

Prolonged Activity

Applied as recommended, the product controls reinfections with Dictyocaulus viviparus, Ostertagia spp. and Oesophagostomum radiatum for up to 28 days, Cooperia spp. and Trichostrongylus spp. for up to 21 days, and Haemonchus placei and Nematodirus helvetianus for up to 14 days. The following species are included within each of the relevant genera: Ostertagia ostertagi, O. lyrata, Cooperia oncophora, C. punctata, C. surnabada, Trichostrongylus axei, T. colubriformis.

For best results use as part of a program to control both internal and external parasites of cattle based on the epidemiology of these parasites.

Contra-indications

This product is formulated only for topical application to beef and dairy cattle, including lactating dairy cattle. Do not use in other animal species. Do not administer orally or by injection. Do not apply to areas of the backline covered with mud or manure.

Special warnings for each target species

The details provided in the ‘Overdose’ section apply.

Care should be taken to avoid the following practices because they increase the risk of development of resistance and could ultimately result in ineffective therapy:

- Too frequent and repeated use of anthelmintics from the same class, over an extended period of time.

- Underdosing, which may be due to underestimation of bodyweight, misadministration of the product, or lack of calibration of the dosing device (if any).

Suspected clinical cases of resistance to anthelmintics should be further investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to another pharmacological class and having a different mode of action should be used.

To date no resistance to eprinomectin (a macrocyclic lactone) has been reported within the EU. However resistance to other macrocyclic lactones has been reported in parasite species in cattle within the EU. Therefore, use of this product should be based on local (regional, farm) epidemiological information about susceptibility of nematodes and recommendations on how to limit further selection for resistance to anthelmintics.

Special precautions for use in animals

Not to be used in other species; avermectins can cause fatalities in dogs.

Special precautions to be taken by the person administering the product

Operators should wear rubber gloves when applying the product. If accidental skin contact occurs, wash the affected area immediately with soap and water. If accidental eye exposure occurs, flush eyes immediately with water. Do not smoke, eat or drink while handling the product.

Wash hands after use. Should clothing become contaminated, remove as soon as possible and launder before re-use. In the event of ingestion, wash out mouth with water and seek medical advice.

Adverse reactions

No undesirable effects have been identified when the product is used at the recommended dose rate.

Use during pregnancy, lactation or lay

May be used in dairy cattle during all stages of lactation. Studies have demonstrated a wide safety margin. Studies conducted at three times the recommended use level of 0.5 mg eprinomectin/kg body weight had no adverse effect on breeding performance of cows or bulls.

Interactions

No interactions with other medicaments and no other forms of interactions are known.

Amounts to be administered and administration route

Administer only by topical application at the dose rate of 1 ml per 10 kg of body weight, corresponding to the recommended dose rate of 0.5 mg eprinomectin per kg body weight. The product should be applied topically by pouring along the backline in a narrow strip extending from the withers to the tailhead. The following dosing packs are available:

Dosing cup with Measure-Squeeze-Pour System (250 ml and 1 litre bottles)

The 250 ml pack contains one 25 ml dosing cup and one dip tube. The 1 litre pack contains one 60 ml dosing cup and one dip tube.

Insert the dip tube into base of the dosing cup. Leave the slotted end of the dip tube exposed in the bottom of the bottle. Unscrew the bottle cap from the top of the bottle. Screw the dosing cup onto the top of the bottle.

Measure: To select the correct dose rate, rotate the adjuster cap at the top of the cup in either direction to position the dose indicator to the weight of the animal you want to treat. When body weight is between markings, use the higher setting.

Squeeze the bottle gently to fill the dosing cup to the required dose. Release your grip and any excess will return to the bottle.

Pour: Apply the full dose by tipping and pouring along the backline of the animal until the dosing cup is empty. The dosing cup should not remain attached to the bottle when not in use. Detach the dosing cup after each use and replace the bottle cap.

Back-pack (2.5 and 5 litre packs)

Connect the dosing gun and draw-off tubing to the back-pack as follows. Attach the open end of the draw-off tubing to an appropriate dosing gun. Attach draw-off tubing to the cap with the stem that is included in the pack. Replace shipping cap with the cap with the draw-off tubing. Tighten the draw-off cap. Gently prime the dosing gun, checking for leaks.

Follow the dosing gun manufacturer’s directions for adjusting the dose and proper use and maintenance of the dosing gun and draw-off tubing.

Rainfall at anytime before or after treatment will not affect the efficacy of the product. The product is intended for use on cattle only. Do not use in other species.

To ensure administration of a correct dose, bodyweight should be determined as accurately as possible; accuracy of the dosing device should be checked.

Overdose

No signs of toxicity appeared when 8-week old calves were treated at up to 5x the therapeutic dose (2.5 mg eprinomectin/kg body weight) 3 times at 7 day intervals. One calf treated once at 10x the therapeutic dose (5 mg/kg body weight) in the tolerance study showed transient mydriasis. There were no other adverse reactions to treatment. No antidote has been identified.

Withdrawal periods

Meat may only be taken for human consumption from 15 days after the last treatment. There is no milk withdrawal period for lactating dairy cattle. Milk from cows may be used for human consumption at any time following treatment.

Pharmaceutical particulars

Excipients

Butylated hydroxytoluene, Propylene glycol octanoate decanoate.

Major incompatibilities

No major incompatibility has been identified.

Shelf life

Shelf life of the veterinary medicinal product as packaged for sale: 3 years.

Special precautions for storage

Keep container in the outer carton. Protect from light. The dosing cup should not be stored attached to the bottle when not in use. Remove the cup after each use and replace with the bottle cap.

Immediate packaging

Eprinex Pour-On for Beef and Dairy Cattle is available in four pack sizes – 250 ml, 1 litre, 2.5 litres and 5 litres.

Disposal

DANGEROUS TO FISH AND AQUATIC LIFE. Do not contaminate surface waters or ditches with the product or used container. Any unused product or waste materials derived from such products should be disposed of in accordance with local requirements.

Marketing authorisation number

Vm 08327/4157.

Legal category

POM-VPS

Company name: Merial Animal Health Ltd

Address: PO Box 327

Sandringham House

Harlow Business Park

Harlow

Essex CM19 5TG

425.20
Order within 10h 40m 2s (before 12AM)
And receive your order
on Thursday 21 November
AIR FREIGHT

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