COVID-19: We are vigilantly monitoring the situation in Europe and have precautions in place for our customers and our employees.
We maintain delivery services and continue to serve with as minimal disruption as possible. Updated May 25, 2020

Vitofyllin 50 mg for dogs 56 tablets

For the improvement of peripheral and cerebral vascular blood circulation. For improvement in dullness, lethargy and overall demeanour in dogs

Prescription required* (Exceptions apply)

Vitofyllin 50 mg film-coated tablets for dogs


Active substance:
Propentofylline 50.00 mg/tablet

Ferric Oxide, yellow, (E 172) 0.075 mg/tablet
Titanium Dioxide, (E171) 0.215 mg/tablet
For a full list of excipients, see section 6.1.


Film-coated tablets.
Yellow, round, convex tablets with cross-snap tab on one and imprinting “50” on the other side.
The tablet can be divided into equal halves and quarters.


4.1 Target species


4.2 Indications for use, specifying the target species

For the improvement of peripheral and cerebral vascular blood circulation. For improvement in dullness, lethargy and overall demeanour in dogs.

4.3 Contraindications

Refer to section 4.7
Do not use in dogs weighing less than 2.5 kg.
Do not use in cases of hypersensitivity to the active substance and/or to any of the other ingredients of the product.

4.4 Special warnings


4.5 Special precautions for use

Special precautions for use in animals

Specific diseases (e.g. kidney disease) should be treated accordingly.
Consideration should be given to rationalising the medication of dogs already receiving treatment for congestive heart failure or bronchial disease.
In the case of renal failure, the dose should be reduced.

Special precautions to be taken by the person administering the veterinary medicinal product to animals

Care should be taken to avoid accidental ingestion.
Wash hands after use.

4.6 Adverse reactions (frequency and seriousness)

On rare occasions, allergic skin reactions, vomiting and cardiac disturbances have been reported. In these cases, the treatment should be stopped.

4.7 Use during pregnancy, lactation or lay

Do not use in pregnant or lactating bitches or breeding animals as the product has not been evaluated in these animals.

4.8 Interaction with other medicinal products and other forms of interaction

None known.

4.9 Amounts to be administered and administration route

The basic dosage is 6-10 mg propentofylline/kg bodyweight, divided into two 3-5mg/kg doses as follows:

Body weight (kg) : Daily total tablets; Daily total dose (mg/kg)

2,5-4: 1/2 tablet (1/4 a.m. and p.m.); 6,3-10

5-7: 1 tablet (1/2 a.m. and p.m.); 7,1-10

8-9: 1 1/2 tablet (3/4 a.m. and p.m.); 8,3-9,4

10-15: 2 tablets (1 a.m. and p.m.); 6,7-10

16-25: 3 tablets (1 1/2 a.m. and p.m.); 6-9,4

26-33: 4 tablets (2 a.m. and p.m.); 6,1-7,7

Dogs of more than 20 kg can be given Vitofyllin 100 mg film-coated tablets for dogs.

The tablets can be administered directly onto the back of the dog's tongue or can be mixed in a small ball of food and should be administered at least 30 minutes before feeding.

4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary

Excitation tachycardia, hypotension, reddening of mucous membranes and vomiting.
The withdrawal of the treatment leads to a spontaneous remission of these signs.

4.11 Withdrawal period(s)

(not applicable)


Pharmacotherapeutic group: peripheral vasodilator; purine derivatives; propentofylline
ATCvet code: QC04AD90

5.1 Pharmacodynamic properties

Propentofylline has been shown to increase blood flow, particularly of the heart and skeletal muscle. It also increases the blood flow of the brain and therefore its oxygen supply, without increasing the brain's glucose demand. It has a modest positive chronotropic effect and a marked positive ionotropic effect. In addition, it has been shown to have an anti-arrhythmic effect in dogs with myocardial ischemia and a bronchodilator action equivalent to that of aminofylline.

Propentofylline inhibits platelet aggregation and improves the flow properties of erythrocytes.
It has a direct effect on the heart and reduces peripheral vascular resistance thereby lowering cardiac load.

Propentofylline may increase willingness to exercise and exercise tolerance, particularly in older dogs.

5.2 Pharmacokinetic particulars

After oral administration propentofylline is fast and completely absorbed and quickly distributed in the tissues. Given orally to dogs, maximum plasma levels are reached already after 15 minutes.
The half-time is about 30 minutes and the bioavailability for the mother substance amounts to about 30%. There are a number of effective metabolites and the biotransformation takes place mainly in the liver. Propentofylline is excreted in form of its metabolites in 80-90% via the kidneys. The rest is eliminated with the faeces. There is no accumulation.


6.1 List of excipients

Lactose monohydrate
Maize Starch
Silica, Colloidal Anhydrous
Magnesium Stearate

Film Coating:
Titanium Dioxide, E171
Ferric Oxide, yellow, E 172
Macrogol 6000

6.2 Incompatibilities

Not applicable.

6.3 Shelf-life

Shelf-life of the veterinary medicinal product as packaged for sale: 5 years

Unused divided tablets should be returned to the blister pack and any divided tablet portions remaining after 72 hours should be discarded.

6.4. Special precautions for storage

Store in the original package (blister) and keep the blister packs in the outer carton and store in a dry place. Divided tablets should be stored in the blister pack.

6.5 Nature and composition of immediate packaging

Polyvinylchloride– PolyVinylidene dichloride /Aluminium blister with 14 tablets, in a cardboard box containing 4 blisters (56 tablets).

Polyvinylchloride– PolyVinylidene dichloride /Aluminium blister with 14 tablets, in a cardboard box containing 10 blisters (140 tablets).

Not all pack sizes may be marketed.

6.6 Special precautions for the disposal of unused veterinary medicinal product or waste materials derived from the use of such products

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.


Animalcare Ltd
10 Great North Way
York Business Park
Nether Poppleton

Order within 13h 53m 44s (before 12AM)
And receive your order
on Tuesday 9 June

Customers who buy this product, usually buy: